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Homocysteine assay

Product Method Size Catalog Price Quantity
Homocysteine assay Enzymatic R1 2x21.7ml, R2 2x4.6ml HY4036 $1312.72
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  • Format
    Liquid ready-to-use
  • Assay Range
    Establish own reference range
  • Working Stability 2-8 °C
    On board stability:28 days at +10°C
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Intended Use

A homocysteine test system is a device intended for the quantitative in vitro determination of homocysteine concentration in human serum. This product is suitable for use on RX series instruments, which includes the RX daytona and the RX imola.

Clinical Significance

Homocysteine is a thio-containing amino acid produced by the intracellular demethylation of methionine. Severely elevated concentrations of total homocysteine are found in patients with homocystinuria, a rare genetic disorder of the enzymes involved in the metabolism of homocysteine. Patients with homocystinuria exhibit mental retardation, early arteriosclerosis and arterial and venous thromboembolism. Other less severe genetic defects which lead to moderately elevated levels of total homocysteine are also found.

Hyperhomocysteinemia, elevated levels of homocysteine, can be associated with an increased risk of CVD. Patients with chronic renal disease experience an excess morbidity and mortality due to arteriosclerotic CVD. Elevated concentration of homocysteine is a frequently observed finding in the blood of these patients. Although such patients lack some of the vitamins involved in the metabolism of homocysteine, the elevated homocysteine levels are mainly due to impaired homocysteine removal from the blood by the kidneys.

Recent evidence has also implicated elevated blood levels of homocysteine in miscarriages and birth defects. Drugs such as methotrexate, carbamazepine, phenytoin, nitrous oxide and 6-azauridine triacetate interfere with homocysteine metabolism and may give elevated levels.

Available Applications

RX series analysers, including:

RX Daytona

RX Imola