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Complement C4 Liquid Assay

Product Method Size Catalog Price
Complement C4 Liquid Assay Immunoturdidimetric R1 1 x 14.2ml, R2 1 x 4.9ml CM8349 POA
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  • Format
    Liquid ready to use
  • Assay Range
    1.5-136.5mg/dl
  • Working Stability 2-8 °C
    Stable to expiry
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Complement Component 4 (liquid) assay - Price on Application (POA)

Intended Use

For the quantitative in vitro determination of Complement C4 concentration in serum. This product is suitable for use on the RX Series instruments which includes the RX daytona and RX imola. Applications are also available for a wide range of other analysers.

Clinical Significance

Complement is a complex biological system which works in conjunction with antibody and other factors to protect the body from invasion by pathogens. When activated by either the classical or alternative pathway complement acts on biological membranes and may cause cell death. The human complement cascade consists of several distinct plasma proteins. Complement C4 levels are important in determining inherited or acquired deficiencies. Conversely, levels may rise in a variety of inflammatory and necrotic disorders as part of the acute-phase plasma protein response.

Principle

Sample is reacted with a buffer containing antibody specific for human complement C4 (B1E-globulin). The absorbance (340nm) of the resulting turbid solution is proportional to the concentration of C4 in the sample. By constructing a standard curve from the absorbance of standards, C4 concentration of sample can be determined.

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