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Bilirubin 2 (Total) (liquid) assay

Product Method Size Catalog Price Quantity
Bilirubin 2 (Total) (liquid) assay Vanadate Oxidation R1 4 x 52.2ml, R2 4 x 20ml BR4061 $134.44
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  • Format
    Liquid ready-to-use
  • Assay Range
    1.55 - 582 μmol/L (0.091 to 34.1 mg/dL)
  • Working Stability 2-8 °C
    Stable to expiry
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Intended Use

For the quantitative in vitro determination of Total Bilirubin in serum and plasma.

Total Bilirubin measurements are used in the diagnosis and treatment of haemolytic, biliary and liver disorders including hepatitis and cirrhosis.

This product is suitable for use on the RX imola analyser.

Clinical Significance

Bilirubin is formed by the breakdown of haemoglobin in the spleen, liver and bone marrow. In the liver, bilirubin is conjugated with glucuronic acid to form a soluble compound. This conjugated bilirubin passes down the bile duct and is excreted into the gastrointestinal tract. An unconjugated, albumin bound form is also present in the circulation. It is insoluble and does not normally pass through the kidneys into the urine.

An increase in bilirubin concentration in the serum or tissues is called jaundice. Jaundice occurs in toxic or infectious diseases of the liver e.g. hepatitis B or obstruction of the bile duct and in rhesus incompatible babies.

Useful information may be obtained by determining which form of bilirubin is elevated.

High levels of conjugated or direct bilirubin indicate that bile is not being properly excreted; therefore an obstruction may be present in the bile duct or gall bladder. Unconjugated or indirect bilirubin can also be determined by subtracting the direct bilirubin level from the total bilirubin result. High levels of unconjugated bilirubin indicate that too much haemoglobin is being destroyed or that the liver is not actively treating the haemoglobin it is receiving.

Available Applications

RX Imola