Home Reagents Beta-2 Microglobulin (B2M) assay
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Beta-2 Microglobulin (B2M) assay

Product Method Size Catalog Price Quantity
Beta-2 Microglobulin (B2M) assay Immunoturbidimetric R1 2x11.6, R2 2x4.9 BM8016 $780.99
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  • Format
    Liquid ready-to-use
  • Assay Range
    0.476 - 20.4mg/l
  • Working Stability 2-8 °C
    Stable to expiry
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Intended Use

Turbidimetric assay for the quantitative in vitro determination of 2Microglobulin in serum. This product is suitable for use on RX series analyser RX suzuka.

Clinical Significance

2Microglobulin is a low molecular weight protein (11800D) found of the surface of all cells except erythrocytes and the trophoblastic layer of the placenta. It is a constituent of the light chain of human histocompatibility antigens HLA, A, B and C. B2M is found on T and B cells and in tumor associated transplantation antigens. 2M may control the expression of antigens on the cell surface and their biosynthesis.

In healthy individuals, B2M is synthesized at a rate of 9 mg/hours and is eliminated mostly by the kidneys.

In AIDS serum, B2M is an accurate predictor of the progression of the disease in HIV infected groups including haemophiliacs. Levels above 5 mg/l indicate rapid progression and poor prognosis.

In various mylomas, B2M levels have been related to tumor mass, prognosis, disease activity and effectiveness of treatment. Levels below 4 mg/l indicate better prognosis than levels above 20 mg/l.

Principle

B2M present in patient samples reacts with the coated latex particles, causing an agglutination that can be measured at 546 nm. The increase in turbidity is proportional to the concentration of B2M in the sample.

Available Applications

RX Suzuka