Ammonia assay (manual)
| Product | Method | Size | Catalog | Price | Quantity |
| Ammonia assay (manual) | Enzymatic UV | 10 x 5ml | AM1015 | $158.33 | |
| Shipping costs will be added at the checkout stage, click here for charges. | |||||
- Format
Lyophilised - Assay Range
Linear to 1180 µmol/l - Working Stability 15-25 °C
5 days - Working Stability 2-8 °C
3 weeks
Intended Use
For the quantitative in vitro determination of Ammonia in plasma. This product is suitable for Manual use.
Clinical Significance
The major source of circulating ammonia is the GI tract. Under normal conditions, ammonia is metabolised to urea by liver enzymes. Several diseases, both inherited and acquired, cause elevated ammonia (hyperammonemia). The inherited deficiencies of urea cycle enzymes are the major cause of hyperammonemia in infants. The acquired hyperammonemia diseases are caused by liver disease, renal failure and Reye’s Syndrome. Elevated ammonia is toxic to the central nervous system.
Principle
Ammonia combines with -ketoglutarate and NADPH in the presence of glutamate dehydrogenase (GLDH) to yield glutamate and NADP+. The corresponding decrease in absorbance at 340 nm is proportional to the plasma ammonia concentration.
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