Albumin assay
| Product | Method | Size | Catalog | Price | Quantity |
| Albumin assay | BCG | 6 x 100ml | AB362 | $60.21 | |
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- Format
Concentrate - Assay Range
0.287 - 7.55 g/L - Working Stability 15-25 °C
3 months - Working Stability 2-8 °C
_
Intended Use
For the quantitative in vitro determination of albumin in serum and plasma. This product is suitable for both manual and automated use and utilizes the bromocresol green method.
Clinical Significance
Albumin is the most abundant serum protein representing 55-65% of the total protein. It is synthesized in the liver and has a half-life of 2 to 3 weeks. The main biological functions of albumin are to maintain the water balance in serum and plasma and to transport and store a wide variety of ligands e.g. fatty acids, calcium, bilirubin and hormones such as thyroxine.
Low levels of albumin in the blood are associated with a variety of diseases. Hypoalbuminemia (low albumin levels) has been implicated in the following conditions: impaired albumin synthesize in the liver; liver disease; kidney disease; malnutrition or malabsorption; generalized shock; inflammation; burns; dermatitis; intestinal disease and Crohns disease. Hyperalbuminemia (high albumin levels) has little diagnostic relevance except, perhaps in dehydration.
Some diabetic patients present with complications, such as kidney failure or anemia, so we at Randox have developed innovative tests that allow the accurate measurement of blood glucose, through secondary markers that are not influenced by such complications. Albumin is a protein with a high binding affinity to glucose. Glycated Albumin (GA) is a glycemic control marker for diabetes mellitus, reflecting the blood glucose status at 2 to 4 weeks, so is more rapid than HbA1c, which is optimal if measured at 6 to 8 weeks. Albumin measurement allows:
- Faster confirmation of results following diet, exercise or medication
- Permits timely adjustment of medication
- Applicable to gestational diabetic patients and diabetic patients with unstable blood glucose levels where HbA1c is not effective
- Suitable for use when HbA1c values are adversely impacted by shortened life spans of red blood cell such is the case in diabetic nephropathy and anemia. In these cases, HbA1c does not accurately reflect blood glucose status and it has been proven that Glycated albumin gives a more useful check for blood glucose control.
Principle
The measurement of serum albumin is based on its quantitative binding to the indicator 3,3',5,5'tetrabromom cresol sulphonephthalein (bromocresol green, BCG). The albuminBCGcomplex absorbs maximally at 578 nm, the absorbance being directly proportional to the concentration of albumin in the sample.
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